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The SARS-CoV-2 infection initiates complex human host-pathogen interactions and alters mitochondrial function with significant disruption of glycolysis/TCA cycle (Warburg effect), affecting several metabolic pathways of amino acid (AA), fatty acid (FA), nucleotide, and antioxidant synthesis 139,140

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Based on our findings, it is reasonable to speculate that TMX (or its metabolites) functions as a nicotinic agonist, activating nAChRs and changing cholinergic transmission to restore normal activity (Khaldoun-Oularbi et al

This can be performed at least 5 days a week for one hour per day