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But "normal" does not mean "ignore it." Acquired oral hyperpigmentation can be benign, but it warrants assessment precisely because it can also represent a more significant clinical clue

Both have also had oral GLP-1 drugs on the market for nearly 20 years and are now banking on injectable GLP-1s for diabetes and weight loss to propel future sales

R.KovacevicB.ChesterJ.et al (2022)

MASH has replaced the old terminology of NASH (non-alcoholic steatohepatitis) and is defined as the presence of 5 % hepato-steatosis and hepatocyte "ballooning" (inflammation with hepatocyte injury and cell liver death) with or without fibrosis [5,6] [Table 2]

Diabetics are treated with a low or highdose of sulfonylurea derivatives and eventually insulin [5]