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Whilst not stated in the paper, it could be possible that the increase in the antioxidant glutathione is compensatory, but the compensatory effect is not enough to combat all of the oxidative damage

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These enzymes form a multienzyme metabolic complex, which translocates to the nucleus during S (DNA replication) and G2/M (DNA damage checkpoint) phases, and is required for biosynthesis of the nucleotide precursor, thymidylate, which is critical to DNA synthesis and repair

The researchers did not observe any serious adverse effects throughout the study