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However, the numerous central effects described for native GLP-1 and for some of the GLP-1RAs in rodents and in humans encourage future clinical trials exploring additional mechanisms that could potentially underlie the beneficial effects observed with this drug class
Feng J, Jin T
[3] The structure of semaglutide is 94% similar to endogenous GLP-1.[4] The 2021 trial protocol for the aforementioned study noted that taste bud cells produce GLP-1, which sends paracrine signals to GLP-1 receptors on gustatory nerve fibres involved in sweet taste perception
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