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The mechanisms underlying hair loss during GLP-1 therapy likely involve multiple contributing factors rather than a single direct drug effect

FIGURE 7 3.4 Correlations of p-Akt and PGC-1 with mitochondrial metabolic function To further investigate the central role of the p-Akt and PGC-1 signaling pathways in regulating cardiac energy metabolism, we performed Pearson correlation analysis between the key signaling molecules and mitochondrial metabolic function indicators

Researchers are particularly interested in its behavior under metabolic stress, where mitochondrial-derived peptides appear to play a regulatory role in how cells adapt energy production to changing demands