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NeuroToxicol 96:2836
A majority of studies looking at association between AMD and GLP-1 agonist use was conducted on patients with type 2 diabetes
For type 2 diabetes , NICE NG28 recommends continuing GLP-1 treatment only if there is adequate response, defined as HbA1c reduction of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight at 6 months
The D-amino acid substitution preserves the spatial orientation of amino acid side chains needed for competitive binding to the FOXO4-p53 interaction surface, maintaining biological activity despite the non-natural backbone (PMID: 28340339)
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