The reasons for Pure PRPs superior comfort profile include: Neutrophils in Regular PRP release inflammatory cytokines (TNF-, IL-1, IL-6) that prolong inflammation and increase pain[8][10] Red blood cells create viscosity in Regular PRP that makes injections more painful and traumatic[1][7] Hemoglobin release from damaged red blood cells causes tissue damage and oxidative stress[7] Pure PRPs cellular purity eliminates these pain-causing components entirely 2
Metabolic: IGF-1 elevation requires monitoring
Vitamin B12 is found primarily in animal-derived foods meat, fish, dairy and eggs
Sikiric, P., Gojkovic, S., Krezic, I., Smoday, I
Blood pressure changes can also be a potential side effect