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19,20 Retatrutide, a triple GLP-1/GIP/glucagon agonist, has demonstrated the greatest reported efficacy to date, with weight loss reaching approximately 24.2% in adult clinical trials

While topical application is convenient and non-invasive, the peptide faces a significant barrier: human skin is designed to keep foreign substances out

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- [DOI] [PubMed] [Google Scholar] 114.Drucker DJ, Asa S