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Peripheral arterial disease and critical limb ischemia represent potential applications based on BPC-157's pro-angiogenic effects and demonstrated improvements in blood flow recovery in hind limb ischemia models

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Another study demonstrated that IGF-1 administration increased overall BDNF and decreased expression of interleukin (IL)-1, TNF-, nitric oxide synthase (iNOS), and glial fibrillary acidic protein (GFAP) in the whole brain [28]