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The grey market problem A significant number of websites sell research peptides in vials with instructions for reconstitution and injection, nominally labelled for research purposes only. In practice, many purchasers use them for personal weight loss or body composition purposes

The protocol for this review was registered with PROSPERO (ID: CRD42023386822)

At 500mcg/mL, a 50mcg dose = 0.1mL (10 units), easily measurable

But the cost can be high because health insurers are reluctant to pay for these drugs, putting strict conditions on prescriptions if they are willing to cover them at all

The medications were further popularized due to their supposed use by various celebrities for cosmetic weight loss purposes