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Atypical melanocytes spread along the basal layer of the surface lining of the mouth

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A synthetic version of exendin-4 now called exenatide proved effective in diabetic mice, then in humans, and received FDA approval in 2005 under the brand name Byetta

These nuances highlight the importance of treating GLP-1s as part of a comprehensive plan rather than a standalone shortcut

Aroda VR, Rosenstock J, Wysham C et al (2016) Efficacy and safety of LixiLan, a titratable fixed-ratio combination of insulin glargine plus lixisenatide in type 2 diabetes inadequately controlled on basal insulin and metformin: the LixiLan-L randomized trial