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Research on its long-term safety remains insufficient

In contrast to the predominantly renal expression of SGLT2, the SGLT1 receptor is expressed mainly in the intestine and to a lesser extent in the S3 segment of the renal proximal tubule and the heart.20 Inhibition of both these receptors increases the percentage of renal glucose elimination through the proximal tubule and, owing to the SGLT1 receptor, also inhibits intestinal absorption of glucose