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In the chronic toxicity experiment, L-NAME caused severe tissue damage (myocardial and hepatic cell necrosis, necrosis of the lymphoid cells in the spleen) while L-arginine provoked predominantly congestion, edema and hemorrhages in all organs

In clinical trials for T2D, pramlintide showed significant weight loss in addition to glucose control warranting its investigation as a treatment for obesity

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COPD causes air to become trapped in the lungs, meaning some air stays in the lungs after exhaling