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The dose is typically higher in months 2 and 3 (moving toward 0.5 mg and then 1.0 mg weekly), which is when most patients report the strongest appetite suppression

Depicts MTHFR variant activity For example, an individual who is heterozygous at both C677T (C/T) and A1298C (A/C), known as a compound heterozygote, is expected to exhibit a 55% decrease in MTHFR enzymatic activity (35% activity due to the presence of one T allele at C677T and 20% activity due to the presence of one C allele at A1298C = 55%)

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Secondary causes, e.g