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While effective for immediate symptom resolution, this approach shuts down endogenous production by triggering a negative feedback loop

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Key benefits for perimenopausal women: Supports faster repair of tendons, ligaments, and muscle tissue that become more injury-prone as estrogen falls Reduces local inflammation through macrophage M1-to-M2 polarization, which may ease joint pain and soft-tissue discomfort common in perimenopause Promotes angiogenesis via endothelial cell migration and tube formation, improving blood supply to areas of chronic or recurring injury Administration method: Subcutaneous injection, typically into the abdomen with rotating injection sites