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The group additionally varied electrospinning speed during fabrication to tune fiber organization through the scaffold depth to provide a shear-resistant superficial layer

Cartilage faces even greater obstacles given avascular nature (no blood vessels penetrating tissue), low cell density (chondrocytes sparse within extensive extracellular matrix), minimal metabolic activity (slow turnover and repair), and mechanical loading challenges (constant stress impeding healing)

Bone spurs from spinal arthritis create similar pressure

From Early Observations to Clinical Standards Above that are early human studies