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Oral VK2735 (Viking Therapeutics) -- Phase 2# VK2735 is unique as the only dual GLP-1/GIP agonist with an oral formulation in clinical development: 12.2% weight loss at 13 weeks (oral tablet) 97% of treatment groups achieved at least 5% weight loss Oral Phase 3 expected Q3 2026 The injectable SC formulation achieved 14.7% at 13 weeks Oral Amycretin (Novo Nordisk) -- Phase 1# Novo Nordisk's oral amycretin demonstrated 13.1% weight loss at just 12 weeks, the highest early-stage oral result

In addition, both TTP and gAgAP downregulated transcription levels of angiotensin II receptor type 1 ( agtr1 ) and miR-132/-212, with TTP producing a comparable reduction in agtr1 to captopril and a significant decrease in miR-132/-212 expression

Routes of Administration: Oral vs

doi:10.1016/j.maturitas.2019.03.008

Progress Photos: Standardized photos (same lighting, angles, clothing) every 2-4 weeks document visual changes that measurements may miss