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Both of these hormones help reduce appetite and regulate how your brain responds to food

Zhang X, Tang S, Zhang Q, et al

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10.1038/s41401-018-0160-1 Summary Keywords berberine, neurodegenerative diseases, neuroinflammation, neuroprotection, oxidative stress Citation Cheng Z, Kang C, Che S, Su J, Sun Q, Ge T, Guo Y, Lv J, Sun Z, Yang W, Li B, Li X and Cui R (2022) Berberine: A Promising Treatment for Neurodegenerative Diseases

Thats how long its been since hypertension got a new mechanistic pathway