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A method for preventing drug-induced ototoxicity in an individual in need thereof comprising intratympanic administration of a pharmaceutical composition comprising a therapeutic agent, wherein the therapeutic agent is an antioxidant or anti-apoptotic agent, wherein the pharmaceutical composition is administered prior to onset of therapy with the drug, and wherein the composition provides sustained release of the therapeutic agent into the ear for a period of at least 5 days after a single administration

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This infers that a more targeted approach, such as using proteinprotein interaction inhibitors that specifically disrupt the NRF2KEAP1 interaction, represents a more viable approach to harnessing the protective power of NRF2 in diabetes prevention