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Approximately half of all critically ill patients in the ICU develop multiple organ dysfunction syndrome (MODS) 2 , which is responsible for 30% of deaths worldwide 3,4

Protocol 3: long-term maintenance (for persistent mild symptoms) Goal: Comfortable long-term adherence with minimal GI disruption

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Unlike traditional insulin secretagogues, Prusogliptin does not directly stimulate insulin release but rather enhances endogenous GLP-1 activity, resulting in a lower risk of hypoglycemia and less likelihood of weight gain

Tirzepatide (Mounjaro) is a dual GIP/GLP-1 receptor agonist currently licensed in the UK for type 2 diabetes only