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In addition to regulating ATII synthesis, angiotensinconverting enzyme (ACE) is primarily responsible for the degradation of a tetrapeptide, acetyl-N-Ser-Asp-Lys-Pro (AcSDKP), an endogenous physiologic inhibitor of hematopoiesis

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Researchers typically start at 250 mcg once daily for the first two to three days to characterise nasal tolerability and response, then move to the target schedule