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Given that fertility involves both partners, the mans weight loss and health improvement on a GLP-1 RA may actually increase the couples chance of conception (and certainly will improve his overall health)

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56 In a study involving 15 healthy subjects and 16 obese men, GLP-1RA infusion following a 9.9 g salt load significantly increased urinary sodium excretion both in healthy subjects (from 74 8 mmol/180 min to 143 18 mmol/180 min

This enables TRPV1-mediated regulation of HSP70 by capsaicin (Bevan et al., 2014) or, less classically, by cannabidiol (Ma et al., 2025)