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doi: 10.3389/fphar.2021.657033 Received 22 January 2021 Accepted 19 May 2021 Published 04 June 2021 Volume 12 - 2021 Edited by Philippe De Deurwaerdere, Universit de Bordeaux, France Reviewed by Habibeh Khoshbouei, University of Florida, United States Gaiqing Wang, The Third Peoples Hospital of Hainan Province, China Updates Copyright 2021 Tan, Fang and Gu