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doi: 10.1096/fj.10-171579 60 ProvenzanoPPAlejandro-OsorioALGrorudKWMartinezDAVailasACGrindelandREet al

By pumping the accumulated, unbound cytosolic catecholamines backward across the plasma membrane and safely into the extracellular synaptic space, the neuron is able to maintain its free cytoplasmic neurotransmitter levels below toxic thresholds , directly protecting itself from oxidative cell death and preserving neuronal viability (Underhill et al., 2021)

During preclinical investigations, they have shown some similar potential benefits

[DOI] [PubMed] [Google Scholar] 38.Weinberger DR, Anxiety at the frontier of molecular medicine

An increase in ROS levels in PCa can lead to the dysregulation of the PI3K signaling pathway