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However, these tests have limitations, including nonspecific readings in the context of polytrauma, limited availability in the acute care setting and minimal mechanistic insight [23, 24]

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Ni acts as a potential trace element and has capability of promoting tumor growth via some mechanisms such as induction of DNA aberration and deletion, inhibition of intercellular transmission mechanism, inhibition of the maintenance of nucleotide excision, oxidative deformation and methylation of DNA