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This process contributes to neurodegeneration in the hippocampus (Prom-In et al., 2020)

Use: Adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in patients with an initial body mass index (BMI) of 30 kg/m 2 or greater (obese) OR 27 kg/m 2 or greater (overweight) in the presence of at least one weight-related comorbidity such as hypertension, type 2 diabetes mellitus, or dyslipidemia

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Inflammation Induction of inflammatory responses in the glomerulus, renal tubular cells, and the surrounding interstitium is another mechanism of drug-induced nephrotoxicity that can lead to fibrosis and renal scarring (Naughton 2008b)

Jan 2021;143:41-46