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Reduced Fat Absorption: GLP-1 medications may limit the absorption of dietary fats, decreasing overall calorie intake from meals

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The working theory is that GLP-1s protect the heart through a combination of better metabolic control, lower inflammation, and direct vascular and cardiac benefits

It says safest depends on individual factors including comorbidities and prior medication tolerability, and that several approved formulations carry distinct pharmacokinetics and side effect patterns