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Under current UK guidance, medications like Wegovy are often prescribed for up to two years

The 9 mg and 12 mg doses have both been validated at 68-week exposure, with a clear signal that 9 mg offers nearly the same efficacy with better tolerability

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These ranges are wide because individual response varies enormously based on starting BMI, metabolic health, adherence, and concurrent lifestyle modifications

FDA labeling indicates no clinically relevant pharmacokinetic changes across the spectrum of hepatic impairment (Child-Pugh classes A-C), and no dose adjustment is recommended based on hepatic function