melenic or melanotic Oral Macule: Symptoms and Treatment Labial melanotic macule

Behera D, Damre A, Varghese A, and Addepalli V (2008) In vitro evaluation of hepatic and extra-hepatic metabolism of coumarins using rat subcellular fractions: correlation of in vitro clearance with in vivo data

Heres the sequence I see repeatedly in practice: candida overgrows it ferments carbohydrates and produces acetaldehyde the liver tries to process it when overwhelmed, the toxin spills into circulation the toxin crosses into the brain, dulling cognitive function and affecting balance Acetaldehyde also drains thiamine (vitamin B1)

However, some individuals can have lasting nerve damage if treatment is delayed after the onset of symptoms

10.1186/s40780-017-0083-x 88 SchmidtR

The oral LD 50 for the rat is 30 - 110 mg/kg body weight, depending on the solvent used