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Researchers found that "MELANOTAN effectively increases the melanin content of skin in those individuals with MC1R variant alleles and therefore, those most in need of photoprotection." [37] Results, released in December 2009, showed that seven of nine patients treated with afamelanotide could tolerate ambient light exposure and had an improve quality of life after 60 days of treatment

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Since the EHR data used in this study does not provide information about patient or clinician behavior, we can only speculate on the potential drivers of such changes

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