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PUD is a multifactorial disease and there is an ongoing demand for the identification of new therapeutic agents for its management (Zatorski 2017)

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Clinically effective ranges (NIH): 250500 mg/day: Maintenance and antioxidant support 500600 mg/day: Skin pigmentation, oxidative stress, immune support Splitting the dose or opting for sustained release or liposomal formats can further enhance absorption and cellular availability

Hughes et al

In addition supplementation of, nutrients those compete with metal(loids), plant growth regulators and signalling molecules, has been helpful in enhancing the tolerance of plants