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Now, in regards to the failed sphincter function after different NSAIDs, and later, to the improved sphincter function and smooth muscle function when BPC 157 was given, BPC 157, as a particular anti-ulcer pentadecapeptide, LD1 could be not achieved, effective alone without carrier (1-7) may be a suitable peptide candidate to additionally rescue such extended NSAIDs toxicity (1-14)