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Research from that same physiology paper found that semaglutide reduces the appetite feedback parameter to 49 kcal per day per kilogram of weight loss, compared to 82-83 kcal per day per kilogram during calorie restriction alone

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It is a single-model, single-group animal finding and has not been tested in controlled human studies

doi: 10.1016/J.BIOCEL.2006.07.001 43 SahooDK