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Activation of these pathways promotes the key of pro-inflammatory cytokines (IL-1, IL-6, and TNF- ) and chemokines (CXC, CC, CX3C, and XC), exacerbating inflammations and tissue injury

Moreover, UV radiation can activate the proopiomelanocortin (POMC) gene and thereby enhance the production of alpha-melanocyte stimulating hormone (-MSH) and adrenocorticotropic hormone (ACTH) which can lead to increased PKA and melanogenesis (Im et al., 2002)

Host genetic factors determining COVID-19 susceptibility and severity

During the catagen phase, the hair follicle undergoes regression and structural changes