Glucagon-like peptide-1 (GLP-1) receptor agonists represent a class of medications increasingly prescribed for type 2 diabetes management and, more recently, for weight loss
Furthermore, it is also hailed as the 2nd Botox. As of this date, no single case of side effects has been documented in a large-scale clinical trial of over 10 000 participants in the UK
In a retrospective cohort study including 7,044 patients with T2D, obesity (BMI 27 kg/m 2 ) and HFpEF, combination therapy with an SGLT2i and GLP-1 RA showed a lower risk of HF exacerbation, all-cause emergency department visits and new-onset kidney injury compared with patients only receiving SGLT2i
This is because Janumet XR contains an extended-release form of metformin, which is often easier to tolerate
Stop use and seek medical advice if you notice chest discomfort, strong palpitations, or severe anxiety after application