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Caspase-3 is often described as an executioner enzyme in the programmed cell death pathway, because once it becomes activated and cleaved, it appears to orchestrate the dismantling of the cell through the proteolytic breakdown of essential structural and regulatory proteins

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To view a copy of this licence, visit About this article Cite this article Sattar, A.A., Matin, A.A., Hadwan, M.H

Astrocytes and microglia in the CNS play an important role in the pathological process of PSD by producing cytokines such as interleukin (IL), tumor necrosis factor (TNF) and interferon (IFN) (Ogodek, 2022