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It alleviates SLI in C57BL/6 mice and reduces serum ALT, AST, ROS, and inflammatory cytokine levels, with its protective effects primarily achieved through inhibition of ferroptosis and oxidative stress via the PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathways (Yin et al., 2025)

Intake of soluble, fermentable dietary fibres enhanced plasma folate concentrations in rats and humans, bacterial load, and total folate content in the colon, but not the whole bodys folate status in piglets 265,266,267

These findings reveal that circadian disruption in adipocytes contributes to systemic metabolic disorders during overnutrition

The fear of side effects is a key reason for poor compliance

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