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These interventions currently include oral rehydration, caffeine, ibuprofen, and anti-emetics

Regulatory agencies expect comprehensive analytical data that confirms structural integrity and detects any variability or impurities

This is done to manage potential side effects (like water retention) and to optimize cost

The model was manually adjusted in Coot and refined against the map by using the real space refinement module with secondary structure and non-crystallographic symmetry restraints in the Phenix package 36

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