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The survey revealed physician resistance to prescribing oral semaglutide, which could explain the relatively low uptake in Japanese clinical practice observed by Fujiwara et al

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Moreover, two PLP-dependent enzymes are required to convert homocysteine to the amino acid cysteine in homocysteine transsulfuration pathway: cystathionine -synthase and cystathionine -lyase ( Figure 5 ) (34)