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Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and sodium-glucose cotransporter-2 (SGLT2) inhibitors are game-changers in the treatment of T2DM and are currently promoted by major clinical guidelines among potential first-line pharmacological options after failure/intolerance to metformin, especially in individuals with an atherosclerotic cardiovascular disease phenotype (GLP-1 RAs) [174]

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At the highest Zepbound dose of 15 mg weekly, results showed: Average weight loss: 22.5% of body weight Breaking down the success rates: 96% lost at least 5% of body weight 89% lost at least 10% of body weight 78% lost at least 15% of body weight 63% lost at least 20% of body weight For someone weighing 220 pounds, losing 22.5% means dropping about 50 pounds to reach 170 pounds

Riluzole: real-world evidence supports significant extension of median survival times in patients with amyotrophic lateral sclerosis

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