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Though rare, serious side effects require prompt medical attention as they can affect organs such as the kidneys, pancreas, gallbladder, and eyes

Injurious effects of curcumin on maturation of mouse oocytes, fertilization and fetal development via apoptosis

In addition, many of the significantly altered canonical pathways in metformin treated SW837 cells are associated with the cellular radioresponse, including cell cycle, cell death and hypoxic signalling

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Funding This work was supported by Science and Technology Key Program of Hunan Province Grants (2016SK2066), Key Projects of Hunan Health Committee (B2017207), Hunan Province Chinese Medicine Research Program Grants (201940), Changsha City Science and Technology Program Grants (kq1801144), Changsha Central Hospital Affiliated to University of South China Foundation of key Program (YNKY201901), Hunan Province Foundation of High-level Health Talent (225 Program), and Science and Technology Key Program of Hunan Provincial Health Committee (20201904)