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The practical takeaway: if the Wegovy pill's administration requirements feel like a barrier for you, it may be worth waiting to see how orforglipron's FDA review unfolds over the next 12 months before making a long-term treatment decision

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A paper published this week in JAMA Psychiatry found semaglutide, the active ingredient in GLP-1 drugs like Ozempic and Wegovy, "significantly improved" motivation in patients with major depressive disorder, or MDD a promising finding because lack of motivation and related disruptions to the brains reward pathways play a critical role in many other psychiatric conditions as well

Bismah Irfan, MD Functional & Integrative Medicine, Houston, TX