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This may be a beneficial effect (bypassing key), resolving a wide range of occlusion/occlusion-like syndromes vessels and multiple organ failures (for review, see [24]) by re-establishing blood flow through the activation of the collateral additional vascular pathways
The pharmacology is well described in the peer-reviewed literature, but clinical effect sizes vary by indication, dosing, individual factors, and adherence, which is a large part of why frequency cannot be generalized
These lesions might be expected to have progressive cartilage wearing and/or subchondral bone damage that could limit the repair and integration capacity of revision tissue engineering therapies applied to the same location, a controversial topic in the field at present
10.1007/s11248-006-0014-3
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