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By week 4, electroacupuncture and OFA demonstrated optimal and consistent effects in preserving joint structure and maintaining cartilage integrity, exhibiting extremely significant differences compared to the OA model group

No significant differences were noted in the secondary outcomes post-weighting between these two groups, with all results consistent across multiple sensitivity analyses

The estimated changes from baseline in HbA 1c were significantly greater with oral semaglutide 3, 7, and 14 mg compared with placebo at week 26 (estimated treatment differences ranging from 1.1 to 1.7%), and were significantly greater with oral semaglutide 14 mg compared with liraglutide 0.9 mg (estimated treatment difference of 0.3%), for the trial product estimand

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Older adults lose muscle mass faster under caloric restriction