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Semaglutide improved symptoms, physical limitations, and led to greater weight loss across diuretic use categories in patients with HFpEF, says study author Kavita Sharma, MD, of Johns Hopkins University School of Medicine, in a release

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8 Concerningly, lifestyle improvements are often difficult to sustain, underscoring the potential benefits of early initiation and background therapy with GLP-1RA due to its benefits on metabolic disorders (Table 3) and chronic liver disease