Just last week, the FDA approved Eli Lillys Foundayo
It simultaneously activates: GLP-1 appetite & cravings control GIP metabolic regulation Glucagon increases calorie burning & fat mobilization This three-lane approach makes Retatrutide fundamentally different from other medications, potentially placing it closer to bariatric-surgery outcomes but without surgery
Oxidative metabolism signatures predict response to 5FU-based chemotherapy treatment Given this robust adaptation to facilitate cellular survival in cancer cells treated with 5FU, we next postulated that elevated mitochondrial metabolism may be a predictor of response to 5FU-based chemotherapy
The irony, as you point out, is that this same rigidness does not apply to other medications that can be prescribed in a more flexible manner
Furthermore, heterozygous knock-in of mutant VCP R155H in mice leads to alterations in mitochondrial respiratory complex activity (Yin et al., 2012)