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Risk of Amputation: There is an increased risk of lower limb amputation (toes, feet) associated with empagliflozin, particularly in patients with prior amputations, peripheral vascular disease, neuropathy, and diabetic foot ulcers

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thus, the type of pharmaceutical formulation (slow or fast release) is also an important consideration

10.1002/(sici)1096-9861(19990111)403:2 3.0.co;2-5 43 Mietlicki-BaaseE