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Regarding their metabolic effects, the combination of a GLP-1RA and a SGLT2i significantly reduces HbA1c level, body weight, and SBP, with an additive effect on weight loss and SBP but not on HbA1c [35, 57,58,59]

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GLP-1 drugs may help curb addiction by targeting reward pathways Options include once-weekly injectables, daily agents, combination therapies with insulin, and newer oral formulations that some patients may prefer, although tolerability and discontinuation remain considerations