Mice given extra GLP-1 (via gene therapy or a GLP-1 agonist drug) developed more oxidative, fatigue-resistant muscle fibers (more Type I fibers), built up greater muscle glycogen stores, and increased mitochondrial biogenesis changes that enhanced their endurance performance (1)
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In vitro, GLP-1GIPLani is indistinguishable from its GLP-1RGIPR co-agonist backbone in relation to incretin receptor signalling and glucose-stimulated insulin secretion, and is equally effective as Lani for inducing PPAR// target gene expression in the presence of the incretin receptors
They are most noticeable during the first week of treatment or shortly after a dose increase