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They operate on entirely separate biochemical pathways: NMN via the NMNAT pathway to NAD+, and glutathione via the glutathione peroxidase antioxidant system

During 12-day induction, no pluripotency gene expression ( Oct4, Sox2, and Nanog ), immature HB markers, and HPC markers were detected, suggesting that the conversion of MEFs to iHeps bypassed the intermediate stem cell stage (Zhong et al., 2024)